Runway look from Ralph Lauren.

More than two decades have passed since Brooke Shields first asked, "You want to know what comes between me and my Calvins?" For 2010, the ultimate American fashion stamp gets the royal treatment from a slew of our favorite designers: Ralph Lauren's prairie-inspired looks; D&G's Wild West styles; Alexander Wang's urban sportswear; Marc Jacobs' '70s street style reinterpreted for Louis Vuitton; delicately draped chambray courtesy of Donna Karan; and, of course, Chloe's head-to-toe nod to classic Americana.—A.W.